EMD Millipore Calbiochem™ Mitochondrial Pyruvate Carrier Inhibitor, UK5099

A cell-permeable α-cyanocinnamate compound that acts as a rapid, active site thiol modifying, time-dependent and non-competitive inhibitor of bi-directional pyruvate transport across plasma membranes in yeast, bacteria, Drosophila, and humans (IC_{50 = 50nM in rat heart mitochondria; Ki ≤ 1µM) with excellent selectivity over monocarboxylates and}

Manufacturer:  EMD Millipore 5.04817.0002

Catalog No. 50-481-70002

Description

A cell-permeable α-cyanocinnamate compound that acts as a rapid, active site thiol modifying, time-dependent and non-competitive inhibitor of bi-directional pyruvate transport across plasma membranes in yeast, bacteria, Drosophila, and humans (IC₅₀ = 50nM in rat heart mitochondria; K_i ≤ 1µM) with excellent selectivity over monocarboxylates and anions. Shown to significantly decrease pyruvate-driven respiration, enhance glucose uptake and activate AMPK (2µM in human myocytes and skeletal muscle myotubes).

See Product Certificates

Specifications

• Description: 99% by HPLC
• Storage Requirements: Protect from Light
• Target Proteins: mitochondria
• Solubility: DMSO

• Format: Bright yellow solid
• Quantity: 25mg
• Molecular Formula: C₁₈H₁₂N₂O₂