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MilliporeSigma™ Calbiochem™ Mitochondrial Pyruvate Carrier Inhibitor, UK5099
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25mg
Description
A cell-permeable α-cyanocinnamate compound that acts as a rapid, active site thiol modifying, time-dependent and non-competitive inhibitor of bi-directional pyruvate transport across plasma membranes in yeast, bacteria, Drosophila, and humans (IC50 = 50nM in rat heart mitochondria; Ki ≤ 1μM) with excellent selectivity over monocarboxylates and anions. Shown to significantly decrease pyruvate-driven respiration, enhance glucose uptake and activate AMPK (2μM in human myocytes and skeletal muscle myotubes).

Specifications
Specifications
Color | Bright Yellow |
Description | 99% by HPLC |
Target Proteins | mitochondria |
Molecular Formula | C18H12N2O2 |
Solubility | DMSO |
Content And Storage | Protect from light |
Form | Solid |
Quantity | 25 mg |
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