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MilliporeSigma™ Calbiochem™ Mitochondrial Pyruvate Carrier Inhibitor, UK5099

Catalog No. 5048170002
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25mg

Description

A cell-permeable α-cyanocinnamate compound that acts as a rapid, active site thiol modifying, time-dependent and non-competitive inhibitor of bi-directional pyruvate transport across plasma membranes in yeast, bacteria, Drosophila, and humans (IC50 = 50nM in rat heart mitochondria; Ki ≤ 1μM) with excellent selectivity over monocarboxylates and anions.

A cell-permeable α-cyanocinnamate compound that acts as a rapid, active site thiol modifying, time-dependent and non-competitive inhibitor of bi-directional pyruvate transport across plasma membranes in yeast, bacteria, Drosophila, and humans (IC50 = 50nM in rat heart mitochondria; Ki ≤ 1μM) with excellent selectivity over monocarboxylates and anions. Shown to significantly decrease pyruvate-driven respiration, enhance glucose uptake and activate AMPK (2μM in human myocytes and skeletal muscle myotubes).
TRUSTED_SUSTAINABILITY

Specifications

Color Bright Yellow
Description 99% by HPLC
Target Proteins mitochondria
Molecular Formula C18H12N2O2
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 25 mg
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