MilliporeSigma™ Calbiochem™ MK-886

Description

A cell-permeable, orally active NSAID that blocks cellular Cox pathway PGE2 production by inhibiting COX-1 and mPGES-1, but not COX-2, activity, as well as suppresses cellular 5-LO pathway activation by inhibiting FLAP, rather than 5-LO, activity.

A cell-permeable, orally active NSAID (nonsteroidal antiinflammatory drug) that blocks cellular Cox pathway PGE2 (prostaglandin E₂) production by inhibiting COX-1 and mPGES-1 (microsomal PGE₂ synthase-1), but not COX-2, activity (IC₅₀ = 8, 2, and 58μM, respectively), as well as suppresses cellular 5-LO (5-Lypoxygenase; Cat. No. 437996) pathway activation by inhibiting FLAP (5-LO-activating protein), rather than 5-LO, activity (<10% by 1μM MK-886). Unlike NSAIDs (nonsteroidal antiinflammatory drugs) that target only COX pathway, MK-886 does not cause gastrointestinal damages when applied in vivo .

Specifications

• Color: White
• Description: 99% by TLC
• Target Proteins: leukotreine biosybthesis
• CAS: 118414-82-7
• Molecular Formula: C₂₇H₃₃ClNO₂S·Na
• Formula Weight: 494g/mol
• Solubility: DMSO or EtOH
• Form: Solid
• Quantity: 5 mg