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MilliporeSigma™ Calbiochem™ MRN-ATM Pathway Inhibitor, Mirin

The MRN-ATM Pathway Inhibitor, Mirin, also referenced under CAS 299953-00-7, controls the biological activity of Mre11, component of the MRN (Mre11-Rad50-Nbs1) complex. This small molecule/inhibitor is primarily used for Cell Structure applications.

Manufacturer:  MilliporeSigma™ 47595410MG

Catalog No. 47-595-410MG


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Description

Description

A cell-permeable pyrimidinone compound that inhibits the exonuclease activity of Mre11, component of the MRN (Mre11-Rad50-Nbs1) complex, and prevents MRN-mediated activation of dimeric ATM (IC50 = 12µM) in cell-free p53 Ser15 phosphorylation assays, while exhibiting little effect against MRN-independent ATM activation in the presence of high DSBs (DNA double strain breaks) or the activity of activated monomeric ATM. Mirin is shown to cause an increase of G2 population in exponentially growing TOSA4 cultures (~1.6-fold at 50µM) and dramatically increase mitotic cell polulation (~10-fold at 25µM) after irradiation of G2 phase U2OS cultures by preventing IR-induced G2/M checkpoint. Mirin exhibits no inhibitory activity against Rad50-associated adenylate kinase or Exonulease III.
Specifications

Specifications

95% by HPLC
Protect from Light
299953-00-7
220.3g/mol
Reddish orange powder
10mg
C10H8N2O2S
DMSO or EtOH
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