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MilliporeSigma™ Calbiochem™ MRN-ATM Pathway Inhibitor, Mirin

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47-595-410MG 10 mg
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Description

The MRN-ATM Pathway Inhibitor, Mirin, also referenced under CAS 299953-00-7, controls the biological activity of Mre11, component of the MRN (Mre11-Rad50-Nbs1) complex. This small molecule/inhibitor is primarily used for Cell Structure applications.

A cell-permeable pyrimidinone compound that inhibits the exonuclease activity of Mre11, component of the MRN (Mre11-Rad50-Nbs1) complex, and prevents MRN-mediated activation of dimeric ATM (IC50 = 12μM) in cell-free p53 Ser15 phosphorylation assays, while exhibiting little effect against MRN-independent ATM activation in the presence of high DSBs (DNA double strain breaks) or the activity of activated monomeric ATM. Mirin is shown to cause an increase of G2 population in exponentially growing TOSA4 cultures (∽1.6-fold at 50μM) and dramatically increase mitotic cell polulation (∽10-fold at 25μM) after irradiation of G2 phase U2OS cultures by preventing IR-induced G2/M checkpoint. Mirin exhibits no inhibitory activity against Rad50-associated adenylate kinase or Exonulease III.
TRUSTED_SUSTAINABILITY

Specifications

Color Reddish-orange
Description 95% by HPLC
CAS 299953-00-7
Molecular Formula C10H8N2O2S
Formula Weight 220.3g/mol
Solubility DMSO or EtOH
Content And Storage Protect from light
Form Powder
Quantity 10 mg
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