Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Protein Purification
  5. Protease Inhibitors and Phosphatase Inhibitors
  6. 47573010MG

MilliporeSigma™ Calbiochem™ MRP1 Inhibitor II, Reversan

Catalog No. 47573010MG Shop All MilliporeSigma Products
Change view
Click to view available options
Quantity:
10 mg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
47-573-010MG 10 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. 47-573-010MG Supplier MilliporeSigma™ Supplier No. 47573010MG
Only null left
Add to Cart
Add to Cart

Description

The MRP1 Inhibitor II, Reversan controls the biological activity of MRP1. This small molecule/inhibitor is primarily used for Cell Structure applications.

A cell-permeable pyrazolopyrimidine that selectively inhibits MRP1. It is shown to increase the efficacy of vincristine and etopiside by 10- to 15-fold and 7- to 10-fold, respectively, over either of these two MRP1 substrate drugs alone in murine models of neuroblastoma (syngenic and human xenografts). As opposed to the majority of inhibitors of multidrug transporters, it is demonstrated that Reversan was not toxic by itself nor did it increase the toxicity of chemotherapeutic drug exposure in mice. Therefore, Reversan represents a new class of nontoxic MRP1 inhibitor, which may be a useful research tool for the study of neuroblastoma and other MRP1-overexpressing drug-refractory tumors.
TRUSTED_SUSTAINABILITY

Specifications

Color Pale Yellow
Molecular Formula C26H27N5O2
Formula Weight 442g/mol
Solubility DMSO
Form Solid
Quantity 10 mg
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.