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MilliporeSigma™ Calbiochem™ mTOR Activator, MHY1485

mTOR Activator, MHY1485, CAS Number: 326914-06-1, is a cell-permeable activator of mTOR that inhibits autophagy by suppressing the fusion between autophagosomes and lysosomes.

Supplier:  MilliporeSigma™ 5.00554.0001

Catalog No. 50-055-40001


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Description

Description

A cell-permeable triazine derivative that is shown to increase cellular mTOR Ser2448 and downstream substrate 4E-BP Thr37/46 phosphorylation level in rat liver Ac2F cells (1 to 2μM for 1 h), affecting culture viability only at much higher concentrations (by 20% after 24 h 20μM treatment). MHY1485 induced cellular LC3-II accumulation in Ac2F is reported to be a result of autophagy inhibition due to reduced fusion between autophagosomes and lysosomes. The mechanism of mTOR activation by MHY1485 is currently unknown.
Specifications

Specifications

Protect from light
Solid
97% by HPLC
387.39g/mol
10 mg
Pale Yellow
C17H21N7O4
DMSO
SDS
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