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MilliporeSigma™ Calbiochem™ Myeloperoxidase Inhibitor-II

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50-490-80001 10 mg
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Description

A 5-fluorotryptamine derivative that inhibits myeloperoxidase/MPO activity (IC50 = 18nM) via direct affinity interaction with enzyme active site heme pyrrole ring D, while exhibiting much reduced affinity toward serotonin reuptake transporter/SERT ( K i

A 5-fluorotryptamine derivative that inhibits myeloperoxidase/MPO activity (IC50 = 18nM) via direct affinity interaction with enzyme active site heme pyrrole ring D, while exhibiting much reduced affinity toward serotonin reuptake transporter/SERT ( K i = 631nM). Kinetic studies reveal that the inhibitor acts as a good one-electron donor for the intermediate Compound I Fe(IV)=O...Por+, facilitating the formation of Compound II (Fe(IV)-OH...Por) and thereby preventing the reduction of Compound I directly to the resting state Fe(IV)...Por via the halogenation cycle, while, on the other hand, behaves as a poor electron donor for Compound II, thereby preventing the completion of the peroxidase cycle by stalling the further reduction of Compound II to the resting state.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
TRUSTED_SUSTAINABILITY

Specifications

Color Light Beige
Description 95% by HPLC
Target Proteins myeloperoxidase
Molecular Formula C12H13FN2O
Solubility DMSO
Content And Storage Protect from light
Form Powder
Quantity 10 mg
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