Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Protein Purification
  5. Protease Inhibitors and Phosphatase Inhibitors
  6. 48041510MG

MilliporeSigma™ Calbiochem™ NF023

Catalog No. 48041510MG
Click to view available options
Quantity:
10 mg

Description

A suramin analog that acts as a selective and direct G-protein antagonist for α-subunits of the Go

A suramin analog that acts as a selective and direct G-protein antagonist for α-subunits of the Go/Gi group (EC50 ∽ 300nM). Suppresses GTPγS binding to recombinant G-protein α-subunits. Acts by inhibiting the formation of the agonist-specific ternary complex (agonist/receptor/G-protein). NF023 does not interfere with the interaction between α-subunits and βγ-dimer but competes with the effector binding site. Also a P2X receptor antagonist (IC50 = 240nM for P2X1; 8.5μM for P2X3 receptor in rat muscle). Causes a concentration dependent inhibition of excitatory junction potentials (IC50 = 4.8 pM).
TRUSTED_SUSTAINABILITY

Specifications

Color Yellow
Description 95% by HPLC
Target Proteins α-subunits of the Go/Gi group of G-protein
Molecular Formula C35H20N4O21S6·6Na
Formula Weight 1162.9g/mol
Solubility H2O
Content And Storage Hygroscopic
Form Solid
Quantity 10 mg
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.