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MilliporeSigma™ Calbiochem™ NF023

Catalog No. 48041510MG Shop All MilliporeSigma Products
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48-041-510MG 10 mg
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Description

A suramin analog that acts as a selective and direct G-protein antagonist for α-subunits of the Go

A suramin analog that acts as a selective and direct G-protein antagonist for α-subunits of the Go/Gi group (EC50 ∽ 300nM). Suppresses GTPγS binding to recombinant G-protein α-subunits. Acts by inhibiting the formation of the agonist-specific ternary complex (agonist/receptor/G-protein). NF023 does not interfere with the interaction between α-subunits and βγ-dimer but competes with the effector binding site. Also a P2X receptor antagonist (IC50 = 240nM for P2X1; 8.5μM for P2X3 receptor in rat muscle). Causes a concentration dependent inhibition of excitatory junction potentials (IC50 = 4.8 pM).
TRUSTED_SUSTAINABILITY

Specifications

Color Yellow
Description 95% by HPLC
Target Proteins α-subunits of the Go/Gi group of G-protein
Molecular Formula C35H20N4O21S6·6Na
Formula Weight 1162.9g/mol
Solubility H2O
Content And Storage Hygroscopic
Form Solid
Quantity 10 mg
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