Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Protein Purification
  5. Protease Inhibitors and Phosphatase Inhibitors
  6. 4804185MG

MilliporeSigma™ Calbiochem™ NF279

Catalog No. 4804185MG Shop All MilliporeSigma Products
Change view
Click to view available options
Quantity:
5 mg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
48-041-85MG 5 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. 48-041-85MG Supplier MilliporeSigma™ Supplier No. 4804185MG
Only null left
Add to Cart
Add to Cart

Description

A suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC50/KB

A suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC50/KB ∽ 1μM in smooth muscle). Effectively discriminates between P2Y and P2X receptors with no effect on α1A adrenoceptors, adenosine A1 and A2B receptors, histamine H1, muscarinic M3 and neuronal nicotinic acetylcholine receptors. Displays a selectivity profile of P2X1 >P2X2 >P2X3 >P2X4 (IC50 = 19 nM, 770 nM, 1.62μM and >300μM, respectively) in Xenopus oocytes pre-incubated with ATP. In rat and human tissues, exhibits a potency profile of rat P2X1 > human P2X1 > > rat P2X2 > rat P2X3 ∽ human P2X7 > > human P2X4. Not degraded by ecto-nucleotidases.
TRUSTED_SUSTAINABILITY

Specifications

Color White
Description 99% by HPLC
Target Proteins P2X receptor
CAS 202983-32-2
Molecular Formula C49H30N6O23S6·6Na
Formula Weight 1401.1g/mol
Solubility DMSO or H2O
Content And Storage Protect from Light, Protect from Moisture
Form Solid
Quantity 5 mg
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.