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MilliporeSigma™ Calbiochem™ NF279

Catalog No. 4804185MG Shop All MilliporeSigma Products
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Quantity:
5 mg

Catalog No. 48-041-85MG

Supplier: MilliporeSigma™ 4804185MG

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Description

A suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC50/KB

A suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC50/KB ∽ 1μM in smooth muscle). Effectively discriminates between P2Y and P2X receptors with no effect on α1A adrenoceptors, adenosine A1 and A2B receptors, histamine H1, muscarinic M3 and neuronal nicotinic acetylcholine receptors. Displays a selectivity profile of P2X1 >P2X2 >P2X3 >P2X4 (IC50 = 19 nM, 770 nM, 1.62μM and >300μM, respectively) in Xenopus oocytes pre-incubated with ATP. In rat and human tissues, exhibits a potency profile of rat P2X1 > human P2X1 > > rat P2X2 > rat P2X3 ∽ human P2X7 > > human P2X4. Not degraded by ecto-nucleotidases.
TRUSTED_SUSTAINABILITY

Specifications

Color White
Description 99% by HPLC
Target Proteins P2X receptor
CAS 202983-32-2
Molecular Formula C49H30N6O23S6·6Na
Formula Weight 1401.1g/mol
Solubility DMSO or H2O
Content And Storage Protect from Light, Protect from Moisture
Form Solid
Quantity 5 mg
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