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MilliporeSigma™ Calbiochem™ NF279

A suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC50/KB

Manufacturer:  MilliporeSigma™ 4804185MG

Catalog No. 48-041-85MG



Description

Description

A suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC50/KB ~ 1µM in smooth muscle). Effectively discriminates between P2Y and P2X receptors with no effect on α1A adrenoceptors, adenosine A1 and A2B receptors, histamine H1, muscarinic M3 and neuronal nicotinic acetylcholine receptors. Displays a selectivity profile of P2X1 >P2X2 >P2X3 >P2X4 (IC50 = 19 nM, 770 nM, 1.62µM and >300µM, respectively) in Xenopus oocytes pre-incubated with ATP. In rat and human tissues, exhibits a potency profile of rat P2X1 > human P2X1 > > rat P2X2 > rat P2X3 ~ human P2X7 > > human P2X4. Not degraded by ecto-nucleotidases.
Specifications

Specifications

99% by HPLC
Protect from Light
Protect from Moisture
P2X receptor
C49H30N6O23S6·6Na
DMSO or H2O
White solid
5mg
202983-32-2
1401.1g/mol
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