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MilliporeSigma™ Calbiochem™ Nicotinamide Phosphoribosyltransferase Inhibitor, FK866

Catalog No. 4819082MG
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:
2mg

The Nicotinamide Phosphoribosyltransferase Inhibitor, FK866, also referenced under CAS 658084-64-1, controls the biological activity of Nicotinamide Phosphoribosyltransferase. This small molecule/inhibitor is primarily used for Neuroscience applications.

A cell-permeable pyridinylacrylamide compound that acts as a selective, allosteric NAPRT/NAMPT (nicotinamide phosphoribosyltransferase) inhibitor (Ki = 0.4nM for the enzyme/substrate complex; Ki = 0.3nM for the free enzyme), while exhibiting no effect toward NPRT (nicotinic acid phosphoribosyltransferase) activity (82% inhibition of NAPRT activity at 10nM vs no inhibition of NPRT activity at 1μM in K-562 extract). FK866 treatment is shown to induce cell death by depleting NAD+ (Cat. Nos. 481911 and 481915) in HepG2 and NIH-3T3 cultures (by >95% after 24 h treatment of 10nM FK866), likewise the addition of exogenous NAD+ is demonstrated to rescue NIH-3T3 and SH-SY5Y from FK866-induced NAD+-depletion and cell death.
TRUSTED_SUSTAINABILITY

Specifications

Color Yellow
Formulation Supplied as a 50 mM (2mg/102.17μl) solution in DMSO.
Description 97% by HPLC
CAS 658084-64-1
Molecular Formula C24H29N3O2
Formula Weight 391.5g/mol
Solubility DMSO
Content And Storage Protect from light
Form Liquid
Quantity 2 mg
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