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MilliporeSigma™ Calbiochem™ Nicotinamide Phosphoribosyltransferase Inhibitor, FK866
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:
2mg
Description
A cell-permeable pyridinylacrylamide compound that acts as a selective, allosteric NAPRT/NAMPT (nicotinamide phosphoribosyltransferase) inhibitor (Ki = 0.4nM for the enzyme/substrate complex; Ki′ = 0.3nM for the free enzyme), while exhibiting no effect toward NPRT (nicotinic acid phosphoribosyltransferase) activity (82% inhibition of NAPRT activity at 10nM vs no inhibition of NPRT activity at 1μM in K-562 extract). FK866 treatment is shown to induce cell death by depleting NAD+ (Cat. Nos. 481911 and 481915) in HepG2 and NIH-3T3 cultures (by >95% after 24 h treatment of 10nM FK866), likewise the addition of exogenous NAD+ is demonstrated to rescue NIH-3T3 and SH-SY5Y from FK866-induced NAD+-depletion and cell death.

Specifications
Specifications
Color | Yellow |
Formulation | Supplied as a 50 mM (2mg/102.17μl) solution in DMSO. |
Description | 97% by HPLC |
CAS | 658084-64-1 |
Molecular Formula | C24H29N3O2 |
Formula Weight | 391.5g/mol |
Solubility | DMSO |
Content And Storage | Protect from light |
Form | Liquid |
Quantity | 2 mg |
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