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MilliporeSigma™ Calbiochem™ Nimesulide Analog, Compound 76

A cell-permeable sulfonanilide that is shown to exhibit an antiproliferative effect against SKBR-3, BT474 and MDA-MB-453, and affects MCF-7 and MDA-MB-231 only at much higher concentrations.

Manufacturer:  MilliporeSigma™ 4822105MG

Catalog No. 48-221-05MG


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Description

Description

A cell-permeable sulfonanilide that is shown to exhibit an antiproliferative effect against three HER-2-positive breast cancer cell lines, SKBR-3, BT474 and MDA-MB-453 (IC50= 0.9, 2.2, and 4.0µM, respectively), and affects two HER-2-negative breast cancer cell lines, MCF-7 and MDA-MB-231 only at much higher concentrations (IC50 = 22.1 and 19.6µM, respectively). The compound is not expected to be a COX-2 inhibitor and its cellular target(s) and mechanism(s) of growth inhibition is yet to be seen.
Specifications

Specifications

95% by HPLC
5mg
C24H32N2O4S
DMSO
Off-white solid
1021926-22-6
444.59g/mol
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