MilliporeSigma™ Calbiochem™ NOX Inhibitor VII, Thr101

Description

A cell-permeable, selenium-to-sulfur substituted Ebselen (Cat

A cell-permeable, selenium-to-sulfur substituted Ebselen (Cat. No. 324483) derivative that exhibits similar NOX2 inhibitory activity as Ebselen by blocking p22 phox c-terminal PRD (proline-rich domain) and p47 phox bis -SH3 interaction. Although less potent than Ebselen in cell-free p22 phox PRD-p47 phox bis -SH3 binding (IC₅₀ = 4 vs. 0.3μM) and NOX2 activity (IC₅₀ = 4 vs. 0.6μM) assays, Thr101 is more potent and NOX2-selective than Ebselen in cell-based assays (Thr101 IC₅₀ /Ebselen IC₅₀ = 0.3/0.5, 3/0.15, 8/no inhibition, 8/0.7μM, respectively, against NOX2, NOX1, NOX4, and NOX5) and exhibits no glutathione peroxidase activity.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Specifications

• Color: Light Brown
• Description: 98% by HPLC
• Target Proteins: blocks p22phox c-terminal PRD (proline-rich domain) and p47phox bis-SH3 interaction
• Molecular Formula: C₁₄H₁₀FNOS
• Solubility: DMSO
• Content And Storage: Protect from light
• Form: Powder
• Quantity: 25 mg