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MilliporeSigma™ Calbiochem™ Orai1/CRAC Blocker, Cpd5J-4

Catalog No. 5306470001 Shop All MilliporeSigma Products
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53-064-70001 10 mg
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Catalog No. 53-064-70001 Supplier MilliporeSigma™ Supplier No. 5306470001
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Description

A non-toxic thiourea derivative that acts as a blocker of Orai1, the pore subunit of Ca2+-release-activated Ca2+ (CRAC) in T

A non-toxic thiourea derivative that acts as a blocker of Orai1, the pore subunit of Ca2+-release-activated Ca2+ (CRAC) in T cells. Exhibits a strong blocking effect on store-operated Ca2+ entry in HeLa-O+S cells and in Th17 cells. Preferentially reduces Th17 differentiation and ameliorates Th17-mediated autoimmune disease. Blocks the infiltration of T cells into the CNS and reduces the number of IL-17 producing cells. Also shown to reduce the expression of retinoic acid receptor-related orphan receptors a (RORa) and RORgt. Reduces the symptoms and delays the onset of experimental autoimmune encephalomyelitis (EAE) in myelin oligodendrocyte glycoproteins 35-55 (MOG35-55) immunized mice (2mg/kg, i.p.).

Please note that the molecular weight for this compound is batch-specific due to variable water content.
TRUSTED_SUSTAINABILITY

Specifications

Color Off-white
Description 98% by HPLC
Target Proteins Orail1
Molecular Formula C16H12N2O3S
Solubility DMSO
Content And Storage Protect from light
Form Powder
Quantity 10 mg
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