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MilliporeSigma™ Calbiochem™ Oxidized ATP (oATP)

Catalog No. 5057580001 Shop All MilliporeSigma Products
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Quantity:
25 mg

Description

A 2',3'-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes

A 2′,3′-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X7 purinergic receptors in J774 mouse macrophages. Does not affect P2γ receptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X7 receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca2+ influx in lymphocytes (˜100μM). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts.
TRUSTED_SUSTAINABILITY

Specifications

Color White
Description 98% by HPLC
Target Proteins P2X7
Molecular Formula C10H14N5O13P3
Solubility H2O
Content And Storage Protect from light
Form Powder
Quantity 25 mg
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