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MilliporeSigma™ Calbiochem™ PD 153035

Catalog No. 2344901MG Shop All MilliporeSigma Products
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Description

An extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; K

An extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression, and oncogenic transformation. A 10mm (500μg/139μl) solution of PD 153035 (Cat. No. 234491) in DMSO is also available.
TRUSTED_SUSTAINABILITY

Specifications

Color White
Description 97% by HPLC
Target Proteins EGFR
CAS 153436-54-5
Molecular Formula C16H14BrN3O2
Formula Weight 360.2g/mol
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 1 mg
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