MilliporeSigma™ Calbiochem™ PI 3-Kδ Inhibitor X, IC87114

Description

The PI 3-Kδ Inhibitor X, IC87114, also referenced under CAS 371242-69-2, controls the biological activity of PI 3-Kδ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

A cell permeable, selective inhibitor of PI 3-Kδ (IC₅₀= 1.82, 0.07, and 1.24 for p110b, p110d, and p110g, respectively, but may also target p110a at concentrations as high as 100μM with less potency) in NB-4 and primary APL cells. It has been reported that the constitutive activation of PI3K/Akt signaling in primary AML cells is predominantly attributable to PI 3-Kδ. Pharmacologic use of PI 3-Kδ inhibitor has been shown to block PI3K/Akt/mTOR signaling and could thereby reduce proliferation and induce apoptosis. A related study further suggests PI 3-Kδ inhibitor as a key therapeutic target among PI 3-K isoforms for allergy- and mast cell-related diseases.

Specifications

• Color: White
• Description: 95% by HPLC
• CAS: 371242-69-2
• Molecular Formula: C₂₂H₁₉N₇O
• Formula Weight: 397.44g/mol
• Solubility: DMSO
• Form: Powder
• Quantity: 5 mg