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MilliporeSigma™ Calbiochem™ PI3Kδ Inhibitor, SW30

Catalog No. 5265595MG Shop All MilliporeSigma Products
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52-655-95MG 5 mg
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Description

The PI3Kδ Inhibitor, SW30 controls the biological activity of PI3Kδ. This small molecule/inhibitor is primarily used for Membrane applications.

A cell permeable, ATP-competitive and selective tolyl quinazolinone inhibitor of PI 3-Kδ (IC50 = 7 nM, 1300 nM, 85000 nM, and 740nM for PI 3-Kδ PI 3-Kγ PI 3-Kα and PI 3-Kβ, respectively) in an enzymatic assay with an EC50 = 16nM for PI 3-Kδ and 2.7μM for PI 3-Kγ in a cell based assay. It elicits an inflammatory marker suppression effect in co-cultures of HUVEC and PBMCs under superantigen stimulated conditions. This compound, at concentrations between 370nM and 10μM, leads to a dose-dependent decrease in E-selectin expression. Furthermore, it is not cytotoxic to HUVEC cells.
TRUSTED_SUSTAINABILITY

Specifications

Color White
Description >95% by HPLC
Molecular Formula C25H21N7O2
Formula Weight 451.48g/mol
Solubility DMSO
Form Solid
Quantity 5 mg
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