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MilliporeSigma™ Calbiochem™ Piceatannol
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Quantity:
1 mg
Description
A cell-permeable, substrate competitive and reversible plant metabolite that inhibits the activity of rat liver protein kinase A catalytic subunit (IC50 = 3μM), PKC (IC50 = 8μM), MLCK (IC50 = 12μM). In RBL-2H3 cells, the selective inhibition of Syk by piceatannol results in inhibition of FceR1-mediated signaling. Also inhibits wheat embryo Ca2+-dependent protein kinase (CDPK) (IC50 = 19μM), and p72 syk (IC50 = 10μM), a non-receptor tyrosine kinase, relative to Lyn in isolated enzyme preparations. Also possesses anti-leukemic properties. Reported to activate sirtuins and promote the survival of eukaryotic cells.

Specifications
Specifications
Color | Off-white |
Description | 95% by HPLC |
Target Proteins | Activity of rat liver protein kinase A catalytic subunit |
CAS | 10083-24-6 |
Molecular Formula | C14H12O4 |
Formula Weight | 244.2g/mol |
Solubility | DMSO or EtOH |
Content And Storage | Protect from light |
Form | Crystalline Solid |
Quantity | 1 mg |
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