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  6. 50615510MG

MilliporeSigma™ Calbiochem™ Pifithrin-μ

Catalog No. 50615510MG
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10mg

Description

Pifithrin-μ, CAS 64984-31-2, is a cell-permeable inhibitor of p53 interaction with Bcl-xL and Bcl-2. Inhibits p53 translocation to mitochondria without affecting the transactivation function of p53.

A cell-permeable sulfonamide that blocks p53 interaction with Bcl-xL and Bcl-2 proteins and selectively inhibits p53 translocation to mitochondria without affecting the transactivation function of p53. Effectively protects against γ radiation-induced cell death in vitro and animal lethality in vivo . Because Pifithrin-μ targets only the mitochondrial branch of the p53 pathway without affecting the important transcriptional functions of p53, it is superior to Pifithrin-α (Cat. No. 506132) in in vivo studies. Shown to selectively interact with inducible HSP70 and disrupt its functions.
TRUSTED_SUSTAINABILITY

Specifications

Color Off-white
Description 95% by HPLC
Target Proteins p53 interaction with Bcl-xL and Bcl-2 proteins
CAS 64984-31-2
Molecular Formula C8H7NO2S
Formula Weight 181.2g/mol
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 10 mg
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