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MilliporeSigma™ Calbiochem™ Pifithrin-μ

Pifithrin-μ, CAS 64984-31-2, is a cell-permeable inhibitor of p53 interaction with Bcl-xL and Bcl-2. Inhibits p53 translocation to mitochondria without affecting the transactivation function of p53.

Manufacturer:  MilliporeSigma™ 50615510MG

Catalog No. 50-615-510MG


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Description

Description

A cell-permeable sulfonamide that blocks p53 interaction with Bcl-xL and Bcl-2 proteins and selectively inhibits p53 translocation to mitochondria without affecting the transactivation function of p53. Effectively protects against γ radiation-induced cell death in vitro and animal lethality in vivo . Because Pifithrin-μ targets only the mitochondrial branch of the p53 pathway without affecting the important transcriptional functions of p53, it is superior to Pifithrin-α (Cat. No. 506132) in in vivo studies. Shown to selectively interact with inducible HSP70 and disrupt its functions.
Specifications

Specifications

95% by HPLC
Protect from Light
p53 interaction with Bcl-xL and Bcl-2 proteins
C8H7NO2S
DMSO
Off-white solid
10mg
64984-31-2
181.2g/mol
SDS
Documents
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