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MilliporeSigma™ Calbiochem™ PIM3 Kinase Inhibitor VII, M-110

Catalog No. 52652610MG Shop All MilliporeSigma Products
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52-652-610MG 10 mg
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Description

A cell-permeable hydroxyphenyl-propylidene-benzohydrazide compound that acts as a potent, ATP-competitive (Ki

A cell-permeable hydroxyphenyl-propylidene-benzohydrazide compound that acts as a potent, ATP-competitive (Ki = 0.3μM), and highly isoform-selective PIM inhibitor (IC50 = 2.5, 2.5, and 0.047μM against PIM1, PIM2, and PIM3, respectively; [ATP] = 10μM), while affecting CK2α2 only at much higher concentrations (IC50 = 5μM, [ATP] = 10μM) and exhibiting little or no activity against a panel of 258 other kinases (<40% inhibition at 5μM). Shown to inhibit PIM3-dependent STAT3 Tyr705 phosphorylation in DU-145 prostate cancer and MiaPaCa2 pancreatic cancer cells (by 73% and 83%, respectively; 10μM for 18 h), while displaying little effect toward STAT3 Tyr694 phosphoylation in 22RV1 cultures.
TRUSTED_SUSTAINABILITY

Specifications

Color Pale Yellow
Description 97% by HPLC
Molecular Formula C22H28ClN5O3
Formula Weight 445.9g/mol
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 10 mg
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