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MilliporeSigma™ Calbiochem™ PK11195

Catalog No. 5059810001 Shop All MilliporeSigma Products
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50-598-10001 10 mg
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Catalog No. 50-598-10001 Supplier MilliporeSigma™ Supplier No. 5059810001
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Description

An isoquinoline carboxamide that acts as a potent ligand for peripheral bezodiazepine receptor (Kd = 20

An isoquinoline carboxamide that acts as a potent ligand for peripheral bezodiazepine receptor (Kd = 20nM). Exhibits anti-inflammatory properties. Binds to monocytes and following lesioning its binding up-regulated in brain macrophages and activated microglia. Shown to enhance the susceptibility of cells to apoptosis induction by DNA damaging agents and can reverse the suppression of apoptosis by Bcl-2. Serves as a ligand of the outer membrane translocator protein and reduces mitochondrial transmembrane potential within 30 minutes of exposure (˜100μM).
TRUSTED_SUSTAINABILITY

Specifications

Color White
Description 98% by HPLC
Target Proteins peripheral bezodiazepine receptor
Molecular Formula C21H21ClN2O
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 10 mg
Product Title
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