MilliporeSigma™ Calbiochem™ Porcn Inhibitor II, C59

A cell-permeable pyridinylphenyl-acetamide that is much more potent than IWP-2 (Cat

Supplier:  MilliporeSigma™ 5.00496.0001

Catalog No. 50-049-60001

Description

A cell-permeable pyridinylphenyl-acetamide that is much more potent than IWP-2 (Cat. No. 681671) in inhibiting MBOAT family member Porcupine-mediated Wnt palmitoylation (IC₅₀ = 74 pM in STF reporter assays using Wnt3a-transfected HEK293). Shown to be effective against Porcn of murine and human, but not xenopus, species and potently inhibit the processing of both canonical and non-canonical Wnt subtypes. C59 is demonstrated to be orally active and effectively suppress MMTV-WNT1 tumor expansion in mice (5mg/kg and 10mg/kg p.o.) in vivo .

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Specifications

• Content And Storage: Protect from light
• Form: Powder
• Description: 99% by HPLC
• Molecular Formula: C₂₅H₂₁N₃O

• Quantity: 10 mg
• Color: Off-white
• Target Proteins: Porcupine (Porcn)-mediated Wnt palmitoylation
• Solubility: DMSO