MilliporeSigma™ Calbiochem™ Porcn Inhibitor II, C59
A cell-permeable pyridinylphenyl-acetamide that is much more potent than IWP-2 (Cat
Supplier: MilliporeSigma™ 5.00496.0001
DescriptionA cell-permeable pyridinylphenyl-acetamide that is much more potent than IWP-2 (Cat. No. 681671) in inhibiting MBOAT family member Porcupine-mediated Wnt palmitoylation (IC50 = 74 pM in STF reporter assays using Wnt3a-transfected HEK293). Shown to be effective against Porcn of murine and human, but not xenopus, species and potently inhibit the processing of both canonical and non-canonical Wnt subtypes. C59 is demonstrated to be orally active and effectively suppress MMTV-WNT1 tumor expansion in mice (5mg/kg and 10mg/kg p.o.) in vivo .
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
|Protect from light|
|99% by HPLC|
|Porcupine (Porcn)-mediated Wnt palmitoylation|
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