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MilliporeSigma™ Calbiochem™ PP2A Activating Ligand, ITH12246

Catalog No. 5060740001 Shop All MilliporeSigma Products
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50-607-40001 10 mg
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Catalog No. 50-607-40001 Supplier MilliporeSigma™ Supplier No. 5060740001
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Description

A cell-permeable, relatively non-toxic, 1,8-naphthyridine derived compound that blocks the inhibitory effect of protein phosphatase inhibitors, such as okadaic acid, on protein phosphatase 2A (PP2A)

A cell-permeable, relatively non-toxic, 1,8-naphthyridine derived compound that blocks the inhibitory effect of protein phosphatase inhibitors, such as okadaic acid, on protein phosphatase 2A (PP2A). Exhibits blood-brain barrier permeability. Protects neurons against β-amyloid peptides (Ab1-42) toxicity and okadaic acid (Cat. No. 459620)-induced tau hyperphosphorylation. Also protects against rotenone and oligomycin A induced neurotoxicity in SH-SY5Y neuroblastoma cells (at ∽300nM). Prevents the development of glutamate-induced neuronal lesions in rat hippocampal slices by up-regulating PP2A (∽ 3.0μM). Shown to reverse the scopolamine-induced memory loss in mice (∽10mg/kg i.p) and significantly reduces the infarct volume in an animal model of stroke (∽2.5mg/kg). Also acts as an inhibitor of acetylcholinesterase activity in Electrophorus electricus (IC50 = 60nM) and human erythrocytes (IC50 = 780nM).
TRUSTED_SUSTAINABILITY

Specifications

Color Off-white
Description 98% by HPLC
Target Proteins PP2A
Molecular Formula C16H19N3O2·HCl
Solubility DMSO
Content And Storage Protect from light
Form Powder
Quantity 10 mg
Product Title
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