MilliporeSigma™ Calbiochem™ PP2A Activating Ligand, ITH12246

Description

A cell-permeable, relatively non-toxic, 1,8-naphthyridine derived compound that blocks the inhibitory effect of protein phosphatase inhibitors, such as okadaic acid, on protein phosphatase 2A (PP2A)

A cell-permeable, relatively non-toxic, 1,8-naphthyridine derived compound that blocks the inhibitory effect of protein phosphatase inhibitors, such as okadaic acid, on protein phosphatase 2A (PP2A). Exhibits blood-brain barrier permeability. Protects neurons against β-amyloid peptides (Ab1-42) toxicity and okadaic acid (Cat. No. 459620)-induced tau hyperphosphorylation. Also protects against rotenone and oligomycin A induced neurotoxicity in SH-SY5Y neuroblastoma cells (at ∽300nM). Prevents the development of glutamate-induced neuronal lesions in rat hippocampal slices by up-regulating PP2A (∽ 3.0μM). Shown to reverse the scopolamine-induced memory loss in mice (∽10mg/kg i.p) and significantly reduces the infarct volume in an animal model of stroke (∽2.5mg/kg). Also acts as an inhibitor of acetylcholinesterase activity in Electrophorus electricus (IC₅₀ = 60nM) and human erythrocytes (IC₅₀ = 780nM).

Specifications

• Color: Off-white
• Description: 98% by HPLC
• Target Proteins: PP2A
• Molecular Formula: C₁₆H₁₉N₃O₂·HCl
• Solubility: DMSO
• Content And Storage: Protect from light
• Form: Powder
• Quantity: 10 mg