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MilliporeSigma™ Calbiochem™ PrCP Inhibitor

Catalog No. 5040440001 Shop All MilliporeSigma Products
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50-404-40001 10 mg
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Catalog No. 50-404-40001 Supplier MilliporeSigma™ Supplier No. 5040440001
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Description

A dichlorobenzimidazolopyrrolidinamide compound

A dichlorobenzimidazolopyrrolidinamide compound that acts as a highly potent PrCP-selective inhibitor (IC50 = 1nM against human PrCP; IC50 = 2 and 8nM against mouse PrCP, respectively, in the absence or presence of 1% mouse serum albumin), presumably via non-covalent catalytic site interaction, while exhibiting no significant potency toward panels of ion channels, receptors, and enzymes, including homologous serine proteases QPP, FAP, PEP, ACE2, DPP4, DPP8, and DPP9 (IC50 >25μM). Oral administration (100mg/kg/d for 5 d) is reported to result in significant food intake reduction and body fat loss among high fat diet-induced obese mice in vivo .
TRUSTED_SUSTAINABILITY

Specifications

Color White
Description 97% by HPLC
Target Proteins PrCP
Molecular Formula C31H33Cl2N5O2
Solubility DMSO
Form Powder
Quantity 10 mg
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