Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
MilliporeSigma Calbiochem Protein Lysine Methyltransferase Inhibitor, UNC0321
A cell-permeable, quinazoline analog that potently and selectively inhibits PKMT G9a (IC50 = 6nM and 9nM in two biochemical assays for CLOT and ECSD, respectively, and Ki = 63 pM, which is approximately 250-fold more potent than a closely-related analog, BIX0129
Manufacturer: MilliporeSigma 4764965MG
Description
A cell-permeable, quinazoline analog that potently and selectively inhibits PKMT G9a (IC50 = 6nM and 9nM in two biochemical assays for CLOT and ECSD, respectively, and Ki = 63 pM, which is approximately 250-fold more potent than a closely-related analog, BIX01294 (Cat. No. 382190)). It inhibits GLP with reduced potency (15nM) and is found to be inactive (IC50 > 40µM) toward other protein lysine and arginine methyltransferases, such as SET7/9 (aH3K4 PKMT), SET8/PreSET7 (aH4K20 PKMT), and PRMT3, as well as JMJD2E (> 1000-fold selectivity) in ECSD enzymatic assays. It also inhibits H3K9me2 accumulation (IC50 = 11,000nM) in MDA-MB-231 cells, in comparison to BIX01294 (IC50 = 500nM).Please note that the molecular weight for this compound is batch-specific due to variable water content.
Specifications
>98% by HPLC | |
Protect from Light | |
C27H45N7O3 |
Light tan solid | |
5mg | |
DMSO |
Provide Content Correction
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Product Title