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MilliporeSigma™ Calbiochem™ RAD51-Stimulatory Compound-1, RS-1

Catalog No. 55351010MG Shop All MilliporeSigma Products
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55-351-010MG 10 mg
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Description

A cell-permeable sulfonamido-benzamide-based allosteric regulator that stimulates DNA binding and recombinase activities of hRAD51 by locking hRAD51 in an active conformation without affecting its active site ATP hydrolysis.

A cell-permeable sulfonamido-benzamide-based allosteric regulator that stimulates DNA binding and recombinase activities of hRAD51 by locking hRAD51 in an active conformation without affecting its active site ATP hydrolysis. Although RS-1 enhances hRAD51 filament formation on ssDNA with or without the cofactor NTP, active filaments and recombinase activity are only induced in the presence of ATP or AMP-PNP, but not with ADP or no cofactors. Shown to promote resistance of primary human neonatal dermal fibroblasts to Cisplatin- (Cat. No. 232120) induced death in a dose-dependent manner. RS-1 is inactive toward related DNA strand exchange proteins scRAD5 and scDMC1 of yeast origin or E. coli RedA.This HDR (homology-directed repair) enhancer, is shown to significantly increase both Cas9 and TALEN-mediated knock-in efficiencies.
TRUSTED_SUSTAINABILITY

Specifications

Color Light Beige
Description 95% by HPLC
CAS 312756-74-4
Molecular Formula C20H16Br2N2O3S
Formula Weight 524.2g/mol
Solubility DMSO or EtOH
Content And Storage Protect from light
Form Solid
Quantity 10 mg
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