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MilliporeSigma™ Calbiochem™ Rad6 Inhibitor, TZ9
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10mg
Description
A cell-permeable triazine compound that directly targets human E2 Ubiquitin-conjugating enzyme Rad6B/HHR6B catalytic site via noncovalent interactions and effectively inhibits Rad6B-Ub thioester bond formation as well as subsequent substrate ubiquitination without affecting UbcH5B/UBE2D2-catalyzed BCA2 ubiquitination. Shown to inhibit the proliferation of high Rad6B-expressing MDA-MB-231 (IC50 = 6μM in 72 h), but not the low Rad6B-expressing, non-transformed MCF10A, via G2/M arrest and apoptosis induction. Two known cellular Rad6 substrates, β-catenin and PCNA, are reported to be downregulated following 24 h inhibitor treatment in MDA-MB-231 cultures (0.5 to 5μM).

Specifications
Specifications
Color | Pale Yellow |
Description | 99% by HPLC |
Target Proteins | Rad6B/HHR6B |
Molecular Formula | C17H14N6O4 |
Solubility | DMSO |
Form | Solid |
Quantity | 10 mg |
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