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MilliporeSigma™ Calbiochem™ RAF Kinase Inhibitor VII

Catalog No. 5530185MG Shop All MilliporeSigma Products
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Quantity:
5 mg

Description

A cell-permeable imidazopyridinyl-urea compound that acts as a potent inhibitor against B-RafV600E activity (IC50 = 1nM) by targeting its ATP-binding pocket and the adjacent lipophilic allosteric site accessible only when the enzyme is in its inactive DFG-out confor

A cell-permeable imidazopyridinyl-urea compound that acts as a potent inhibitor against B-RafV600E activity (IC50 = 1nM) by targeting its ATP-binding pocket and the adjacent lipophilic allosteric site accessible only when the enzyme is in its inactive DFG-out conformation. Reported to effectively inhibit RafV600E-dependent ERK phosphorylation (IC50 = 610nM) and growth of human melanoma WM266.4 cells (GI50 = 470nM).
TRUSTED_SUSTAINABILITY

Specifications

Color Caramel
Molecular Formula C21H15ClF3N5O3S
Form Powder
Quantity 5 mg
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