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MilliporeSigma™ Calbiochem™ Rho Inhibitor II, Y16

Catalog No. 5040430001 Shop All MilliporeSigma Products
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50-404-30001 10 mg
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Catalog No. 50-404-30001 Supplier MilliporeSigma™ Supplier No. 5040430001
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Description

A cell-permeable pyrazolidinedione compound that is shown to target RhoGEF DH-PH domain junction with high affinity (Kd = 65nM) and effetively prevent RhoGEFs LARG, p115, and PDZ from interacting with RhoA, while displaying little potency against DBL-RhoA, LBC-RhoA, intersectin-Cdc42, or TrioN-Cdc42 interact

A cell-permeable pyrazolidinedione compound that is shown to target RhoGEF DH-PH domain junction with high affinity (Kd = 65nM) and effetively prevent RhoGEFs LARG, p115, and PDZ from interacting with RhoA, while displaying little potency against DBL-RhoA, LBC-RhoA, intersectin-Cdc42, or TrioN-Cdc42 interaction. Shown to completely prevent serum-induced activation of cellular RhoA, but not Cdc42 or Rac1, in NIH-3T3 cultures (10μM) and RhoA downstream signaling events. Greatly synergizes with Rho GEF-binding domain blocker Rhosin (Cat. No. 555460) in blocking RhoA-LARG interaction and in preventing cellular RhoA activation (both drug at 5μM).
TRUSTED_SUSTAINABILITY

Specifications

Color Orange
Description 95% by HPLC
Target Proteins RhoGEF
Molecular Formula C24H20N2O3
Formula Weight 384.4g/mol
Solubility DMSO
Content And Storage Protect from light
Form Powder
Quantity 10 mg
Product Title
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