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MilliporeSigma™ Calbiochem™ Rosiglitazone

Catalog No. 55736610MG Shop All MilliporeSigma Products
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55-736-610MG 10 mg
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Catalog No. 55-736-610MG Supplier MilliporeSigma™ Supplier No. 55736610MG
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Description

A thiazolidinedione compound that acts as an anti-diabetic agent and serves as a potent and selective agonist of peroxisome proliferator-activated receptor-γ (PPARγ) (Kd ∽40 nM) in fat cells.

A thiazolidinedione compound that acts as an anti-diabetic agent and serves as a potent and selective agonist of peroxisome proliferator-activated receptor-g (PPARg) (Kd ∽40 nM) in fat cells. Shown to reduce fatty acid uptake and ameliorate lipid metabolism and insulin resistance in animal models of type II diabetes. Reported to activate both a1- and a2-containing AMPK complexes. Unlike troglitazone, it does not induce the activity of P4503A4. Significantly improves the differentiation of C3H10T1/2 stem cells into adipocytes. Shown to block estrogen synthesis by interfering with androgen binding to aromatase, but without affecting aromatase mRNA or protein expression.
TRUSTED_SUSTAINABILITY

Specifications

Color White
Description 99% by HPLC
CAS 155141-29-0
Molecular Formula C18H19N3O3S·C4H4O4
Formula Weight 473.5g/mol
Solubility DMSO
Content And Storage Protect from light
Form Powder
Quantity 10 mg
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