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MilliporeSigma™ Calbiochem™ Rottlerin

Catalog No. 55737010MG Shop All MilliporeSigma Products
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Description

Rottlerin, CAS 82-08-6, is a cell-permeable, reversible inhibitor of protein kinase C with greater selectivity for PKCδ(IC50= 3-6μM) and PKCθ. Has about 10-fold lower potency against other isozymes.

A cell-permeable and reversible protein kinase C inhibitor that exhibits greater selectivity for PKCδ (IC50 = 3-6μM) and PKCθ. Inhibits the PKCα, PKCβ, and PKCγ isoforms, but with significantly reduced potency (IC50 = 30-42μM). Has reduced inhibitory activity on PKCε, PKCη , and PKCζ (IC50 = 80-100μM). Also known to inhibit CaM kinase III (IC50 = 5.3μM).
TRUSTED_SUSTAINABILITY

Specifications

Color Orange
Description 98% by HPLC
Target Proteins PKCδ
CAS 82-08-6
Molecular Formula C30H28O8
Formula Weight 516.5g/mol
Solubility DMSO or EtOH
Form Solid
Quantity 10 mg
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