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MilliporeSigma™ Calbiochem™ SB 202190

Catalog No. 5593881MG Shop All MilliporeSigma Products
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55-938-81MG 1 mg
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Catalog No. 55-938-81MG Supplier MilliporeSigma™ Supplier No. 5593881MG
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Description

SB 202190, CAS 152121-30-7, is a potent, reversible, competitive inhibitor of p38. Inhibits p38 phosphorylation of myelin basic protein. Blocks the activity of p38β (K

A potent, reversible, competitive, and cell-permeable inhibitor of p38 MAP kinase. Inhibits p38 phosphorylation of myelin basic protein (MBP) with no effect on the activity of the ERK or JNK MAP kinase subgroups. Also inhibits the kinase activity of p38β (Ki = 16nM; IC50 = 350nM) and p38 phosphorylation of activating transcription factor 2 (ATF-2; IC50 = 280nM). Blocks LPS-induced TNF-α and interleukin biosynthesis. Reported to induce LDL receptor expression in Hep52 cells. A 1mg/mL solution of SB 202190 (Cat. No. 559397) in anhydrous DMSO is also available.
TRUSTED_SUSTAINABILITY

Specifications

Color Pale Yellow
Description 98% by HPLC
Target Proteins p38β
CAS 152121-30-7
Molecular Formula C20H14FN3O
Formula Weight 331.3g/mol
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 1 mg
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