MilliporeSigma Calbiochem SB 202190
SB 202190, CAS 152121-30-7, is a potent, reversible, competitive inhibitor of p38. Inhibits p38 phosphorylation of myelin basic protein. Blocks the activity of p38β (K
Manufacturer: MilliporeSigma 5593881MG
DescriptionA potent, reversible, competitive, and cell-permeable inhibitor of p38 MAP kinase. Inhibits p38 phosphorylation of myelin basic protein (MBP) with no effect on the activity of the ERK or JNK MAP kinase subgroups. Also inhibits the kinase activity of p38β (Ki = 16nM; IC50 = 350nM) and p38 phosphorylation of activating transcription factor 2 (ATF-2; IC50 = 280nM). Blocks LPS-induced TNF-α and interleukin biosynthesis. Reported to induce LDL receptor expression in Hep52 cells. A 1mg/mL solution of SB 202190 (Cat. No. 559397) in anhydrous DMSO is also available.
|98% by HPLC|
|Protect from Light|
|Pale yellow solid|
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