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MilliporeSigma™ Calbiochem™ SB 202190

SB 202190, CAS 152121-30-7, is a potent, reversible, competitive inhibitor of p38. Inhibits p38 phosphorylation of myelin basic protein. Blocks the activity of p38β (K

Manufacturer:  MilliporeSigma™ 5593881MG

Catalog No. 55-938-81MG


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Description

Description

A potent, reversible, competitive, and cell-permeable inhibitor of p38 MAP kinase. Inhibits p38 phosphorylation of myelin basic protein (MBP) with no effect on the activity of the ERK or JNK MAP kinase subgroups. Also inhibits the kinase activity of p38β (Ki = 16nM; IC50 = 350nM) and p38 phosphorylation of activating transcription factor 2 (ATF-2; IC50 = 280nM). Blocks LPS-induced TNF-α and interleukin biosynthesis. Reported to induce LDL receptor expression in Hep52 cells. A 1mg/mL solution of SB 202190 (Cat. No. 559397) in anhydrous DMSO is also available.
Specifications

Specifications

98% by HPLC
Protect from Light
p38β
C20H14FN3O
DMSO
Pale yellow solid
1mg
152121-30-7
331.3g/mol
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