MilliporeSigma™ Calbiochem™ SB 242084 Hydrochloride

Catalog No. 50-641-70001

Supplier: MilliporeSigma™ 5.06417.0001

Description

A selective, brain-penetrant 5-HT_2C receptor antagonist (pK

A selective, brain-penetrant 5-HT_2C receptor antagonist (pKi 8.2-9.0 ), with some effects on the 5-HT_2B receptor (pKi 6.8-7.0) and 5-HT_2A receptor (pKi 6.1-6.8). SB 242084 has been shown to increase the effectiveness of the selective serotonin reuptake inhibitor (SSRI) class of antidepressants, and may also reduce their side effects. In animal studies, SB-242,084 produced stimulant-type activity and reinforcing effects, somewhat similar to but much weaker than cocaine or amphetamines. In vivo (ocular) IC₅₀ values reported at 2.08μM.

Specifications

• Color: Pale Yellow
• Description: 98% by HPLC
• Target Proteins: 5-HT2C
• Molecular Formula: C₂₁H₁₉ClN₄O₂·HCl
• Solubility: H₂O
• Content And Storage: Protect from light
• Form: Solid
• Quantity: 10 mg