Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Protein Purification
  5. Protease Inhibitors and Phosphatase Inhibitors
  6. 5064150001

MilliporeSigma™ Calbiochem™ SB-269970 Hydrochloride

Catalog No. 5064150001 Shop All MilliporeSigma Products
Click to view available options
:
10mg

Description

A selective 5-HT7 receptor antagon

A selective 5-HT7 receptor antagonist. Extremely potent in vivo and in vitro . Chronic or acute (even single dose) administration of SB269970 induces functional desensitization of the 5-HT7 receptor system, which precedes changes in the receptor density. This mechanism may be responsible for the rapid antidepressant-like effect of the 5-HT7 antagonist in animal models. SB-269970 is an analogue of SB-258719 and has been shown to have at least 100 fold selectivity versus all other 5-HT receptor subtypes except the human 5-HT5A receptor (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B).
TRUSTED_SUSTAINABILITY

Specifications

Color Off-white
Description 98% by HPLC
Target Proteins 5-HT7
Molecular Formula C18H28N2O3S·HCl
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 10 mg
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.