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MilliporeSigma™ Calbiochem™ SB-269970 Hydrochloride

Catalog No. 5064150001 Shop All MilliporeSigma Products
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50-641-50001 10 mg
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Catalog No. 50-641-50001 Supplier MilliporeSigma™ Supplier No. 5064150001
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Description

A selective 5-HT7 receptor antagon

A selective 5-HT7 receptor antagonist. Extremely potent in vivo and in vitro . Chronic or acute (even single dose) administration of SB269970 induces functional desensitization of the 5-HT7 receptor system, which precedes changes in the receptor density. This mechanism may be responsible for the rapid antidepressant-like effect of the 5-HT7 antagonist in animal models. SB-269970 is an analogue of SB-258719 and has been shown to have at least 100 fold selectivity versus all other 5-HT receptor subtypes except the human 5-HT5A receptor (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B).
TRUSTED_SUSTAINABILITY

Specifications

Color Off-white
Description 98% by HPLC
Target Proteins 5-HT7
Molecular Formula C18H28N2O3S·HCl
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 10 mg
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