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MilliporeSigma™ Calbiochem™ β-Secretase Substrate IV, Fluorogenic

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Catalog No. Quantity
56-575-81MG 1 mg
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Catalog No. 56-575-81MG

Supplier: MilliporeSigma™ 5657581MG

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Description

β-Secretase Substrate IV, Fluorogenic, is a highly sensitive FRET substrate. Hydrolysis of the substrate (Leu-Asp cleavage) by β-secretase results in fluorescence enhancement.

A highly sensitive fluorescence resonance energy transfer (FRET) peptide substrate, based on the EVNLDAEF sequence derived from the β-secretase site of the Swedish mutation of Amyloid Precursor Protein (APP). Hydrolysis of the substrate (Leu-Asp cleavage) by β-secretase results in fluorescence enhancement. kcat/Km values (min-1/μM) at 37°C, pH 4.5, for pro-memapsin 2 and its activated species Leu28p-memapsin 2 are 0.044 and 0.040, respectively.
TRUSTED_SUSTAINABILITY

Specifications

Color Red
Formulation Supplied as a trifluoroacetate salt.
Description 95% by HPLC
Target Proteins β-secretase substrate
Molecular Formula C91H129N25O25S
Formula Weight 2005.2g/mol
Solubility DMSO
Content And Storage Protect from light
Form Lyophilized
Quantity 1 mg
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