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MilliporeSigma™ Calbiochem™ SHIP2 Inhibitor II, CPDA

Catalog No. 5083180001 Shop All MilliporeSigma Products
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50-831-80001 10 mg
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Catalog No. 50-831-80001 Supplier MilliporeSigma™ Supplier No. 5083180001
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Description

A cell-permeable aminopyridine acetamide based compound that acts as an inhibitor of SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2) that can overcome insulin resistance in 3T3-L1 adipocytes.

Enhances insulin-stimulated Akt phosphorylation (Thr308) in TNFa-treated 3T3-L1 adipocytes (∽10μM) and in primary cultured neurons from rat cerebral cortex. Improves glucose tolerance in db/db mice (∽300mg/kg b.i.d) without affecting their fasting glucose levels. Also reduces the expression levels of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase.
TRUSTED_SUSTAINABILITY

Specifications

Color White
Description 98% by HPLC
Target Proteins SHIP2
Molecular Formula C20H15ClF2N2O2
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 10 mg
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