MilliporeSigma™ Calbiochem™ SIRT2 Inhibitor II, AK-1

Description

The SIRT2 Inhibitor II, AK-1, also referenced under CAS 330461-64-8, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications.

A cell permeable, benzylsulfonamide that inhibits SIRT2 activity (IC₅₀= 12.5μM through enzymatic assay) by targeting the SIRT2 nicotinamide binding site, but may also target SIRT1 and SIRT3 (IC₅₀ >40μM) with much less potency. Western analysis illustrates that treatment with AK-1 (> 25μM) leads to an increase in acetylated tubulin. AK-1 (1 to 10μM) is shown to rescue neuronal dysfunction in two in vivo models of Huntington's Disease (HD) in Dropshila and Caenorhabditis elegans. It also demonstrates recovery of neuronal toxicity in a primary model of HD from 1μM to 4μM similar to that of genetic SIRT2 inhibition, and also correlates with the negative regulation of sterol biosynthesis.

Specifications

• Color: Off-white
• Description: >95% by HPLC
• CAS: 330461-64-8
• Molecular Formula: C₁₉H₂₁N₃O₅S
• Formula Weight: 403.45g/mol
• Solubility: DMSO
• Form: Solid
• Quantity: 10 mg