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  6. 57312110MG

MilliporeSigma™ Calbiochem™ SMER28

Catalog No. 57312110MG
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Quantity:
10 mg

Description

A cell-permeable quinazoline compound that augments the cytostatic effects of Rapamycin and acts as an autophagy stimulator both in mammalian cultures

A cell-permeable quinazoline compound that augments the cytostatic effects of Rapamycin (Cat. Nos. 553210 and 553211) in Saccharomyces cerevisiae and acts as an autophagy stimulator both in mammalian cultures in vitro and in a Drosophila melanogaster HD model in vivo . Although SMER28 and Rapamycin do exhibit additive effects on the clearance of cellular autophagy substrates, SMER28 functions independently of Rapamycin by presumably acting on celluar target(s) downstream of the Rapamycin/FKBP12 target, mTOR.
TRUSTED_SUSTAINABILITY

Specifications

Color Pale Yellow
Description 95% by HPLC
CAS 307538-42-7
Molecular Formula C11H10BrN3
Formula Weight 264.1g/mol
Solubility DMSO or EtOH
Content And Storage Protect from light
Form Solid
Quantity 10 mg
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