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MilliporeSigma™ Calbiochem™ Spautin-1

Catalog No. 56756910MG Shop All MilliporeSigma Products
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56-756-910MG 10 mg
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Description

A quinazolin compound that acts as a specific and potent inhibitor of autophagy and promotes Vps34 PI 3-kinase complex degradation by blocking the activity of USP 10 (IC50 = 580nM) and USP 13 (IC50 = 690nM) deubiquitinating enzymes

A quinazolin compound that acts as a specific and potent inhibitor of autophagy and promotes Vps34 PI 3-kinase complex degradation by blocking the activity of USP 10 (IC50 = 580nM) and USP 13 (IC50 = 690nM) deubiquitinating enzymes. However, it does not affect the lipid kinase activity of Vps34. Also shown to reduce the level of cytoplasmic and nuclear p53. Sensitizes breast cancer cell lines (BCAP37, MCF-7, and BT549) to apoptosis under conditions of nutritional deprivation. Also shown to inhibit etoposide-induced cell death in Bax/Bak double knockout (DKO) cells. Normal cell lines (e.g., MDCK cells) do not undergo autophagy in the presence of Spautin-1.
TRUSTED_SUSTAINABILITY

Specifications

Color Off-white
Description 99% by HPLC
Molecular Formula C15H11F2N3
Formula Weight 271.26g/mol
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 10 mg
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