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MilliporeSigma™ Calbiochem™ Src Inhibitor, PP1

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56-780-91MG 1 mg
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Description

The Src Inhibitor PP1, also referenced under CAS 172889-26-8, controls the biological activity of Src. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

A cell-permeable pyrazolopyrimidine compound that is shown to inhibit Src family tyrosine kinases Lck, Fyn, Hck, and Src (IC50 = 5, 6, 20, and 170 nM, respectively), as well as non-Src family kinases such as CSK, RIP2, and CK1δ (IC50 = 640 nM, 26 nM, 170 nM, respectively), in in vitro kinase assays. At 1μM, in vitro kinase activity is reduced by more than 57% for p38α, p38β, CK1δ, CSK, RIP2, and GAK, while exhibiting much lower activity against more than 60 other kinases. Kinetic studies employing Src and [poly Glu-Tyr 4:1] indicate that the inhibition is mixed competitive with respect to the substrate and non-competitive with respect to ATP. PP1 also demonstrates anti-growth properties in several B lymphoma cultures of human and murine origins (IC50 = 2.5 to 8.0μM) and pediatric brain tumor cells (IC50 = 1.1 to 9.7μM). Also available in InSolution™ format (Cat. No. 539741).
TRUSTED_SUSTAINABILITY

Specifications

Color Off-white
Description 90% by HPLC
CAS 172889-26-8
Molecular Formula C16H19N5
Formula Weight 281.36g/mol
Solubility DMSO
Form Solid
Quantity 1 mg
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