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MilliporeSigma™ Calbiochem™ SRT1720

Catalog No. 56786010MG Shop All MilliporeSigma Products
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56-786-010MG 10 mg
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Description

SRT1720, CAS 925434-55-5, is a cell-permeable inhibitor of the mitochondrial SIRT3. Inhibition is AceCS2-competitive (Ki = 0.56μM; Km = 2.44μM), but NAD+-uncompetitive (Ki = 0.34μM; Km = 280μM).

A cell-permeable quinolinecarboxamide compound that is shown to inhibit the mitochondrial SIRT3 in a substrate AceCS2-competitive ( K i = 0.56μM; K m = 2.44μM), but NAD+-uncompetitive ( K i = 0.34μM; K m = 280μM), manner. Also reported to decrease cellular p53 Lys382 acetylation (Effective conc. = 10μM in U2OS and MEF cultures) and inhibit p300 HAT activity (IC50 = 9μM) in vitro , as well as offer therapeutic benefits in several murine and rodent type 2 diabetes models (100mg/kg/dayl p.o.) in vivo . Whether and how SRT1720 activates SIRT1 activity remains uncertain. Also available as a 25mm solution in DMSO (Cat. No. 530748).
TRUSTED_SUSTAINABILITY

Specifications

Color Yellow
Description 97% by HPLC
CAS 925434-55-5
Molecular Formula C25H23N7OS
Formula Weight 469.6g/mol
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 10 mg
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