MilliporeSigma™ Calbiochem™ Suramin, Sodium Salt

Description

A reversible and competitive inhibitor of protein tyrosine phosphatases.

A reversible and competitive inhibitor of protein tyrosine phosphatases. An anti-neoplastic, anti-angiogenic agent that uncouples G-proteins from receptors presumably by blocking their interaction with intracellular receptor domains. Inhibits GDP-GTP exchange, the rate limiting step in the activation of G_α-subunits. A competitive inhibitor of reverse transcriptase. Reported to inhibit topoisomerases I and II. Inhibits Ca²⁺-ATPase in sarcoplasmic reticulum membranes. Also inhibits the cell-surface binding of various growth factors, including EGF, PDGF, and TGF-β. An inhibitor of phospholipase D (IC₅₀ = 15μM). Reported to interact with ATP-binding enzymes and P₂-purinergic receptors. An effective inhibitor of angiogenesis in the calmodulin assay when given in combination with angiostatic steroids.

Specifications

• Color: White
• Description: 98% by HPLC
• Target Proteins: protein tyrosine phosphatases
• CAS: 129-46-4
• Molecular Formula: C₅₁H₃₄N₆O₂₃S₆·6Na
• Formula Weight: 1429.2g/mol
• Solubility: H₂O
• Content And Storage: Hygroscopic
• Form: Crystalline Solid
• Quantity: 50 mg