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EMD Millipore Calbiochem™ Suramin, Sodium Salt

A reversible and competitive inhibitor of protein tyrosine phosphatases.

Manufacturer:  EMD Millipore 57462550MG

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Catalog No. 57-462-550MG


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Specifications

Description

A reversible and competitive inhibitor of protein tyrosine phosphatases. An anti-neoplastic, anti-angiogenic agent that uncouples G-proteins from receptors presumably by blocking their interaction with intracellular receptor domains. Inhibits GDP-GTP exchange, the rate limiting step in the activation of Gα-subunits. A competitive inhibitor of reverse transcriptase. Reported to inhibit topoisomerases I and II. Inhibits Ca2+-ATPase in sarcoplasmic reticulum membranes. Also inhibits the cell-surface binding of various growth factors, including EGF, PDGF, and TGF-β. An inhibitor of phospholipase D (IC50 = 15µM). Reported to interact with ATP-binding enzymes and P2-purinergic receptors. An effective inhibitor of angiogenesis in the calmodulin assay when given in combination with angiostatic steroids.
Description & Specifications

Specifications

98% by HPLC
Hygroscopic
protein tyrosine phosphatases
C51H34N6O23S6·6Na
H2O
White crystalline solid
50mg
129-46-4
1429.2g/mol
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