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MilliporeSigma™ Calbiochem™ Suramin, Sodium Salt
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Quantity:
50 mg
Description
A reversible and competitive inhibitor of protein tyrosine phosphatases. An anti-neoplastic, anti-angiogenic agent that uncouples G-proteins from receptors presumably by blocking their interaction with intracellular receptor domains. Inhibits GDP-GTP exchange, the rate limiting step in the activation of Gα-subunits. A competitive inhibitor of reverse transcriptase. Reported to inhibit topoisomerases I and II. Inhibits Ca2+-ATPase in sarcoplasmic reticulum membranes. Also inhibits the cell-surface binding of various growth factors, including EGF, PDGF, and TGF-β. An inhibitor of phospholipase D (IC50 = 15μM). Reported to interact with ATP-binding enzymes and P2-purinergic receptors. An effective inhibitor of angiogenesis in the calmodulin assay when given in combination with angiostatic steroids.

Specifications
Specifications
Color | White |
Description | 98% by HPLC |
Target Proteins | protein tyrosine phosphatases |
CAS | 129-46-4 |
Molecular Formula | C51H34N6O23S6·6Na |
Formula Weight | 1429.2g/mol |
Solubility | H2O |
Content And Storage | Hygroscopic |
Form | Crystalline Solid |
Quantity | 50 mg |
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