MilliporeSigma™ Calbiochem™ Tankyrase1/2 Inhibitor V, WIKI4

A cell-permeable triazole derivative that acts as a reversible TNKS inhibitor (IC₅₀ = 15nM) and selectively inhibits Wnt/β-catenin, but not NF-κB, TGFβ, or retinoic acid, signaling pathway-dependent transcription activ

Supplier:  MilliporeSigma™ 5.00556.0001

Catalog No. 50-055-60001

Description

A cell-permeable triazole derivative that acts as a reversible TNKS inhibitor (IC₅₀ = 15nM) and selectively inhibits Wnt/β-catenin, but not NF-κB, TGFβ, or retinoic acid, signaling pathway-dependent transcription activity. Both WIKI4 and XAV939 (Cat. No. 575545) are shown to induce basal axin1/2 protein accumulation in DLD1 colon cancer cells (2.5μM; 2 to 4 h) and prevent Wnt3a-induced axin1 protein degradation and β-catenin accumulation in A375 melanoma cells (1μM; up to 24 h) with similar potency. Likewise, WIKI4 also effectively inhibits the Wnt/β-catenin pathway-dependent growth of DLD1 (by 67% in 10 days;1μM).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Specifications

• Content And Storage: Protect from light
• Color: Pale Yellow
• Target Proteins: TNKS2
• Formula Weight: 521.59g/mol

• Form: Powder
• Description: 98% by HPLC
• Molecular Formula: C₂₉H₂₃N₅O₃S
• Solubility: DMSO