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MilliporeSigma™ Calbiochem™ Tau Aggregation Inhibitor, ATPZ, Cpd16

Catalog No. 58022210MG Shop All MilliporeSigma Products
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Quantity:
10 mg

Catalog No. 58-022-210MG

Supplier: MilliporeSigma™ 58022210MG

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Description

A water soluble (32uM in water) BBB-permeable ATPZ (aminothienopyridazine) tau aggregation inhibitor

A water soluble (32uM in water) BBB-permeable ATPZ (aminothienopyridazine) tau aggregation inhibitor that exhibited IC50 of 8.1uM in a heparin-induced tau assembly assay (monitored by thioflavine-T binding and fluorescence), and was further validated in vitro to reduce tau fibril formation (tau fragment K18PL, and full length tau40) by >50% in sedimentation assays. It also displayed very good B/P ratio (1.6) in a mice full PK study with good oral bioavailability and good metabolic stability. No cytotoxicity was observed at up to 100uM in HEK-293 cells.
TRUSTED_SUSTAINABILITY

Specifications

Color Orange
Description 95% by HPLC
Molecular Formula C16H13ClN4O2S
Formula Weight 360.82g/mol
Solubility DMSO
Form Powder
Quantity 10 mg
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