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MilliporeSigma™ Calbiochem™ Temozolomide
A cell-permeable, orally bioavailable, blood-brain barrier-permeant MTIC [5-(3-methyltriazen-1-yl-)-imidazole-4-carboxamide] prodrug whose in vivo DNA alkylating activity is employed in anticancer ther
Supplier: MilliporeSigma™ 5.00609.0001
Description
A cell-permeable, orally bioavailable, blood-brain barrier-permeant MTIC [5-(3-methyltriazen-1-yl-)-imidazole-4-carboxamide] prodrug whose in vivo DNA alkylating activity is employed in anticancer therapy. MGMT ( O 6-methylguanine DNA methyl transferase) repairs TMZ-damaged DNA lesion by covalently transferring O 6-methylation on guanine residues to a cysteine residue on the MGMT, forming the basis of TMZ-resistance in cancer treatment.Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Specifications
| Off-white | |
| DNA guanine residues | |
| 194.2g/mol | |
| Protect from light | |
| 50 mg |
| 99% by HPLC | |
| C6H6N6O2 | |
| DMSO | |
| Solid |
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