Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Protein Purification
  5. Protease Inhibitors and Phosphatase Inhibitors
  6. 61646310MG

MilliporeSigma™ Calbiochem™ TGF-β RI Kinase Inhibitor IX

Catalog No. 61646310MG Shop All MilliporeSigma Products
Change view
Click to view available options
Quantity:
10 mg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
61-646-310MG 10 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. 61-646-310MG Supplier MilliporeSigma™ Supplier No. 61646310MG

Description

A cell-permeable pyridinyloxypyridine compound that acts as a potent and highly selective inhibitor against TGFβ RI/ALK5 (IC50 = 72 nM, [ATP] = 1 mM) by targeting both the ATP-binding site and the selectivity pocket, while exhibiting much reduced or little activity against a panel of 75 other kinases (IC50 <1μM).

A cell-permeable pyridinyloxypyridine compound that acts as a potent and highly selective inhibitor against TGFβ RI/ALK5 (IC50 = 72 nM, [ATP] = 1 mM) by targeting both the ATP-binding site and the selectivity pocket, while exhibiting much reduced or little activity against a panel of 75 other kinases (IC50 <1μM). Shown to reduce TGFβ1-induced nuclear translocation of a GFP-Smad2 fusion reporter in MDA-MB-468 cells (IC50 = 22nM) in vitro and exhibit excellent oral bioavailability (F = 75%, AUC = 4.95μM.h) with low clearance (12 ml/min/kg) in rats in vivo .
TRUSTED_SUSTAINABILITY

Specifications

Color Off-white
Description 95% by HPLC
Molecular Formula C18H18N4O3S
Formula Weight 370.4g/mol
Solubility DMSO
Content And Storage Protect from light
Form Powder
Quantity 10 mg
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.