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MilliporeSigma™ Calbiochem™ TNP-470

Catalog No. 65427010MG Shop All MilliporeSigma Products
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65-427-010MG 10 mg
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Catalog No. 65-427-010MG Supplier MilliporeSigma™ Supplier No. 65427010MG

Description

TNP-470, CAS 129298-91-5, is a cell-permeable Fumagillin (Cat. No. 344845) analog that specifically inhibits MetAP2 methionine aminopeptidase activity (IC50 = 1nM for human MetAP2).

A cell-permeable Fumagillin (Cat. No. 344845) analog that inhibits MetAP2, but not MetAP1, methionine aminopeptidase activity (IC50 = 1nM against human MetAP2), without affecting the inhibitory activity of MetAP2 against HRI- (heme-regulated inhibitor kinase) catalyzed eIF-2α phosphorylation. A potent endothelial cytostasis inducer (IC50 = 25 pM and 37 pM, respectively, against HUVEC and bovine BAEC) in vitro and an effective anti-angiogenesis agent in vivo (2 to 100mg/kg in mice and rats; s.c.).
TRUSTED_SUSTAINABILITY

Specifications

Color White to Light Yellow
Description 97% by HPLC
CAS 129298-91-5
Molecular Formula C19H28CINO6
Formula Weight 401.9g/mol
Solubility DMSO
Form Solid
Quantity 10 mg
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