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MilliporeSigma™ Calbiochem™ Topoisomerase IIα Inhibitor, TSC24

Catalog No. 61485210MG Shop All MilliporeSigma Products
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61-485-210MG 10 mg
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Description

The Topoisomerase IIα Inhibitor, TSC24 controls the biological activity of Topoisomerase. This small molecule/inhibitor is primarily used for Cell Structure applications.

A cell-permeable, TSC (thiosemicarbazone) derivative that acts as a selective and ATP competitive Topoisomerase IIα inhibitor and Fe chelator. Independent of its Fe chelating ability, this compound is shown to block Topo II&alpha-catalyzed ATP hydrolysis by competing with ATP for binding to the ATPase domain of Topo IIα (Kd = 18μM). It also displays M phase cell-cycle arrest at 1μM in nocodazole-treated HT-29 cells. This compound demonstrates anti-proliferative activity, without distinct or obvious selectivity, towards HeLa, HL-60, SGC7901, and HT-29 cultures (IC50 = 90 nM, 50 nM, 30 nM, and 20 nM, respectively), and a broader panel of tumor cell lines with IC50 values in the nanomolar range.
TRUSTED_SUSTAINABILITY

Specifications

Color Yellow
Description 95% by HPLC
Molecular Formula C13H14N4S
Formula Weight 258.34g/mol
Solubility DMSO
Form Powder
Quantity 10 mg
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