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MilliporeSigma™ Calbiochem™ Transglutaminase 2 Inhibitor, ZDON

Catalog No. 6164675MG Shop All MilliporeSigma Products
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61-646-75MG 5 mg
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Description

A cell-permeable, peptide-based, irreversible inhibitor of transglutaminase 2 (TG2; IC50 = 150nM for recombinant TG2). Reacts with the active site cysteine of TG2.

A cell-permeable, peptide-based (Z- QVPL) irreversible inhibitor of transglutaminase 2 (TG2) (IC50 = 150nM for recombinant TG2) that acts by reacting with the active site cysteine of TG2. Exhibits far less potency against TG1 and TG3. Shown to significantly increase PGC-1a and cytochrome c mRNA levels in Q7 and Q111 cells (∽50 mM). Also shown to enhance cytochrome c promoter activity by 250% in Q111 cells. Exhibits protective effect in cells exposed to 3-nitropropionic acid and NMDA, however, it does not directly affect mitochondrial bioenergetics.
TRUSTED_SUSTAINABILITY

Specifications

Color Off-white
Description 98% by HPLC
Molecular Formula C31H45N7O9
Solubility DMSO
Form Powder
Quantity 5 mg
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