Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Protein Purification
  5. Protease Inhibitors and Phosphatase Inhibitors
  6. 6164675MG

MilliporeSigma™ Calbiochem™ Transglutaminase 2 Inhibitor, ZDON

Catalog No. 6164675MG
Click to view available options
Quantity:
5 mg

Description

A cell-permeable, peptide-based, irreversible inhibitor of transglutaminase 2 (TG2; IC50 = 150nM for recombinant TG2). Reacts with the active site cysteine of TG2.

A cell-permeable, peptide-based (Z- QVPL) irreversible inhibitor of transglutaminase 2 (TG2) (IC50 = 150nM for recombinant TG2) that acts by reacting with the active site cysteine of TG2. Exhibits far less potency against TG1 and TG3. Shown to significantly increase PGC-1a and cytochrome c mRNA levels in Q7 and Q111 cells (∽50 mM). Also shown to enhance cytochrome c promoter activity by 250% in Q111 cells. Exhibits protective effect in cells exposed to 3-nitropropionic acid and NMDA, however, it does not directly affect mitochondrial bioenergetics.
TRUSTED_SUSTAINABILITY

Specifications

Color Off-white
Description 98% by HPLC
Molecular Formula C31H45N7O9
Solubility DMSO
Form Powder
Quantity 5 mg
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.