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MilliporeSigma™ Calbiochem™ TrkB Agonist, 7,8-Dihydroxyflavone

A cell permeable flavone based compound with neurotrophic and neuroprotective properties

Manufacturer:  MilliporeSigma™ 5.06300.0001

Catalog No. 50-630-00001

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A cell permeable flavone based compound with neurotrophic and neuroprotective properties. Mimicks the action of Brain Derived Neurotrophic Factor (BDNF) and acts as a TrkB receptor agonist. Due to its lipophilic nature, it can cross the blood-brain barrier. Binds to the extra cellular domain of TrkB with high affinity and promotes its dimerization and autophosphorylation. Potentiates TrkB, but not TrkA, signaling in mouse brain slices. Its neurotropic effects are abolished in the presence of K252a. Suppresses apoptosis in human and rodent neurons and in stably transfected TrkB murine cell line T48 (EC50 = 35nM). Selectively reduces the basal GABAergic transmission due to its suppressive effect on presynaptic GABA release. However, it does not affect glutamatergic transmission.


98% by HPLC
Protect from Light
Yellow powder
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