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MilliporeSigma™ Calbiochem™ TrkB Agonist, 7,8-Dihydroxyflavone

Catalog No. 5063000001 Shop All MilliporeSigma Products
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50-630-00001 100 mg
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Catalog No. 50-630-00001 Supplier MilliporeSigma™ Supplier No. 5063000001
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Description

A cell permeable flavone based compound with neurotrophic and neuroprotective properties

A cell permeable flavone based compound with neurotrophic and neuroprotective properties. Mimicks the action of Brain Derived Neurotrophic Factor (BDNF) and acts as a TrkB receptor agonist. Due to its lipophilic nature, it can cross the blood-brain barrier. Binds to the extra cellular domain of TrkB with high affinity and promotes its dimerization and autophosphorylation. Potentiates TrkB, but not TrkA, signaling in mouse brain slices. Its neurotropic effects are abolished in the presence of K252a. Suppresses apoptosis in human and rodent neurons and in stably transfected TrkB murine cell line T48 (EC50 = 35nM). Selectively reduces the basal GABAergic transmission due to its suppressive effect on presynaptic GABA release. However, it does not affect glutamatergic transmission.
TRUSTED_SUSTAINABILITY

Specifications

Color Yellow
Description 98% by HPLC
Target Proteins TrkB
Molecular Formula C15H10O4
Solubility DMSO
Content And Storage Protect from light
Form Powder
Quantity 100 mg
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