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MilliporeSigma™ Calbiochem™ TRPC3 Channel Inhibitor III, Pyr10

Catalog No. 64849410MG Shop All MilliporeSigma Products
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64-849-410MG 10 mg
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Description

A cell-permeable pyrazole derivative that acts as a selective blocker of the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca2+ entry) and inhibits Carbachol- (

A cell-permeable pyrazole derivative that acts as a selective blocker of the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca2+ entry) and inhibits Carbachol- (Cat. No. 212385) induced Ca2+ entry in TRPC3-expressing HEK293 cells (IC50 = 0.72μM; by Fura-2), while exhibiting much reduced potency against Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 13.08μM; by Fura-2). A great complement to Pyr2 (Cat. No. 203890), Pyr 3 (Cat. No. 648490), and Pyr6 (Cat. No. 203891) in Ca2+ signaling studies.
TRUSTED_SUSTAINABILITY

Specifications

Color Orange-brown
Description 98% by HPLC
Target Proteins TRPC3
Molecular Formula C18H13F6N3O2S
Formula Weight 449.4g/mol
Solubility DMSO
Content And Storage Protect from light
Form Semi-solid
Quantity 10 mg
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